PET/CT in Evaluation of Gastrointestinal Stromal Tumors (GISTs) Tumors

Surgical Treatment of Gastrointestinal Stromal Tumors (GISTs)

Gastrointestinal stromal tumors (GISTs) of the colon.

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. Although they may arise anywhere of GI tract, colonic presentation is infrequent. We report 2 new cases of colonic GISTs localized at descending and sigmoid colon. Endoscopic biopsies were diagnostic for GISTs and no distant metastasis were observed. Both cases underwent resective ...

Gastrointestinal stromal tumors (GISTs) and second malignancies

Several evidences showed that patients with gastrointestinal stromal tumors (GISTs) develop additional malignancies. However, thorough incidence of second tumors remains uncertain as the possibility of a common molecular pathogenesis.A retrospective series of 128 patients with histologically proven GIST treated at our institution was evaluated. Molecular analysis of KIT and PDGFR-α genes was pe...

Histological and Immunological Evaluation of Gastrointestinal Stromal Tumors

Background: Gastrointestinal stromal tumors (GISTs) constitute the majority of gastrointestinal mesenchymal tumors. They usually express a proto-oncogen protein called CD117 detected by immunohistochemistry. This study investigated the differentiation of GISTs as well as the risk of aggressive behaviors in GISTs from surgically-treated patients in university affiliated hospitals. Methods: The c...

Synchronous sporadic gastrointestinal stromal tumors (GISTs) of the colon.

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract originating from the cell of Cajal [1]. Up to 75% of cases are driven by constitutional activation of the proto-oncogene cKIT; 10% by a mutation of the gene encoding for the platelet-derived growth factor receptor (PDGFRA); 12% are wild-type and their pathogenesis has been related to mutations of t...